Structure of PDB 5t8e Chain A

Receptor sequence
>5t8eA (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIA
RELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
3D structure
PDB5t8e Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives.
ChainA
Resolution2.71 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 77U A L704 N705 L707 Q711 M745 F764 L873 T877 L34 N35 L37 Q41 M75 F94 L203 T207 PDBbind-CN: -logKd/Ki=9.14,IC50=0.72nM
BindingDB: IC50=0.720000nM,EC50=0.190000nM
External links
PDB RCSB:5t8e, PDBe:5t8e, PDBj:5t8e
PDBsum5t8e
PubMed28363748
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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