Structure of PDB 5t6g Chain A

Receptor sequence
>5t6gA (length=174) Species: 524364 (Norovirus Hu/1968/US) [Search protein sequence]
HHAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSSIA
IHQAGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLA
VRMGAIASMRIQGRLVHGQSGMLLTGANAKGMDLGTIPGDCGAPYVHKRG
NDWVVCGVHAAATKSGNTVVCAVQ
3D structure
PDB5t6g Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors.
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N40 A H30 E54 I109 Q110 R112 V114 T134 C139 H157 A158 A159 A160 H32 E56 I111 Q112 R114 V116 T136 C141 H159 A160 A161 A162 PDBbind-CN: -logKd/Ki=5.96,IC50=1.1uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5t6g, PDBe:5t6g, PDBj:5t6g
PDBsum5t6g
PubMed27914364
UniProtQ83883|POLG_NVN68 Genome polyprotein (Gene Name=ORF1)

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