Structure of PDB 5t6f Chain A

Receptor sequence
>5t6fA (length=165) Species: 524364 (Norovirus Hu/1968/US) [Search protein sequence]
HAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSSIAI
HQAGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLAV
RMGAIASMRIQGRLVHGQSGMLLLGTIPGDCGAPYVHKRGNDWVVCGVHA
AATKSGNTVVCAVQA
3D structure
PDB5t6f Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N38 A E54 I109 Q110 R112 T134 I135 P136 C139 H157 A158 A159 A160 T161 V168 E55 I110 Q111 R113 T126 I127 P128 C131 H149 A150 A151 A152 T153 V160 PDBbind-CN: -logKd/Ki=5.80,IC50=1.6uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5t6f, PDBe:5t6f, PDBj:5t6f
PDBsum5t6f
PubMed27914364
UniProtQ83883|POLG_NVN68 Genome polyprotein (Gene Name=ORF1)

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