Structure of PDB 5t5g Chain A

Receptor sequence
>5t5gA (length=143) Species: 9606 (Homo sapiens) [Search protein sequence]
SKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVV
EYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRL
GRLINHSKSGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDY
3D structure
PDB5t5g Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 75P A Y286 C311 Y312 M313 R336 L337 N339 T348 Y375 Y377 Y52 C77 Y78 M79 R102 L103 N105 T114 Y141 Y143 PDBbind-CN: -logKd/Ki=5.89,Kd=1.3uM
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5t5g, PDBe:5t5g, PDBj:5t5g
PDBsum5t5g
PubMed27804297
UniProtQ9NQR1|KMT5A_HUMAN N-lysine methyltransferase KMT5A (Gene Name=KMT5A)

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