Structure of PDB 5t4v Chain A

Receptor sequence
>5t4vA (length=112) Species: 9606 (Homo sapiens) [Search protein sequence]
MQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDFFT
MKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGA
VLRQARRQAEKM
3D structure
PDB5t4v Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.
ChainA
Resolution1.65 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 N48 A V657 P658 E661 N708 F714 V30 P31 E34 N81 F87 MOAD: ic50=60nM
PDBbind-CN: -logKd/Ki=7.22,IC50=60nM
BindingDB: IC50=60nM
External links
PDB RCSB:5t4v, PDBe:5t4v, PDBj:5t4v
PDBsum5t4v
PubMed28068087
UniProtP55201|BRPF1_HUMAN Peregrin (Gene Name=BRPF1)

[Back to BioLiP]