Structure of PDB 5t4u Chain A

Receptor sequence
>5t4uA (length=112) Species: 9606 (Homo sapiens) [Search protein sequence]
MQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDFFT
MKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGA
VLRQARRQAEKM
3D structure
PDB5t4u Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 12Q A V657 P658 N708 F714 V30 P31 N81 F87 MOAD: ic50=4800nM
PDBbind-CN: -logKd/Ki=5.32,IC50=4800nM
BindingDB: IC50=4800nM
External links
PDB RCSB:5t4u, PDBe:5t4u, PDBj:5t4u
PDBsum5t4u
PubMed28068087
UniProtP55201|BRPF1_HUMAN Peregrin (Gene Name=BRPF1)

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