Structure of PDB 5t4i Chain A

Receptor sequence
>5t4iA (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
AVLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMGDADR
KHCKFKPDPNIPPTFSAFNEDYVGSGWSRGAMAPAGNNKFSSKAMAETFY
LSNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVSGPLTLPQTRGDGK
KIVSYQVIGEDNVAVPSHLYKVILARRSSVSTEPLALGAFVVPNEAIGFQ
PQLTEFQVSLQDLEKLSGLVFFPHLDRTSDIRNICSVDTCKLLDFQEFTL
YLSTRKIEGARSVLRLEKIMENLKNAEIEPDDYFMSRYEKKLEELKA
3D structure
PDB5t4i A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease.
ChainA
Resolution2.389 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C112 A140 N162 N171 E179
Catalytic site (residue number reindexed from 1) C53 A81 N103 N112 E120
Enzyme Commision number 3.1.30.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R109 S137 R138 G139 A140 A144 G145 K148 F168 N171 S172 N176 R314 R50 S78 R79 G80 A81 A85 G86 K89 F109 N112 S113 N117 R255
BS02 dna A D169 S172 L311 K315 D110 S113 L252 K256
BS03 MN A A140 N171 A81 N112
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5t4i, PDBe:5t4i, PDBj:5t4i
PDBsum5t4i
PubMed28466855
UniProtQ9Y2C4|EXOG_HUMAN Nuclease EXOG, mitochondrial (Gene Name=EXOG)

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