Structure of PDB 5t45 Chain A

Receptor sequence

>5t45A (length=708) Species: 9031 (Gallus gallus)

KLVWVPSEKHGFEAASIKEEKGDEVTVELQENGKKVTLSKDDIQKMNPPK
FSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVINPYKQLPI
YSEKIIDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAG
KTENTKKVIQYLAVVASSPYGELEKQLLQANPILEAFGNAKTVKNDNSSR
FGKFIRINFDVTGYIVGANIETYLLEKSRAIRQAKDERTFHIFYYLIAGA
SEQMRNDLLLEGFNNYTFLSNGHVPIPAQQDDEMFQETLEAMTIMGFTEE
EQTSILRVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTD
FTRSILTPRIKVGRDVVQKAQTKEQADFAIEALAKAKFERLFRWILTRVN
KALDKTKRQGASFLGILDIAGFEIFEINSFEQLCINYTNEKLQQLFNHTM
FILEQEEYQREGIEWNFIDFGLDLQPCIELIERPTNPPGVLALLDEECWF
PKATDTSFVEKLIQEQGNHAKFQKSKDKTEFCILHYAGKVTYNASAWLTK
NMDPLNDNVTSLLNQSSDKFVADLWKDRTVGQLYKEQLTKLMTTLRNTNP
NFVRCIIPNHEKRAGKLDAHLVLEQLRCNGVLEGIRICRQGFPNRIVFQE
FRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTG
VLAHLEEE

3D structure

• PDB: 5t45 Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.
• Chain: A
• Resolution: 2.8 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): S179 G180 T184 N242 S245 S246 G468 E470
• Catalytic site (residue number reindexed from 1): S147 G148 T152 N195 S198 S199 G421 E423

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	52E	A	M89 L95 S117 L119 F493 M497 E501 G709 V710 E712 G713 I714 C717 P722	M57 L63 S85 L87 F446 M450 E454 G630 V631 E633 G634 I635 C638 P643
BS02	MG	A	T184 S246	T152 S199
BS03	BEF	A	S179 K183 S245 S246	S147 K151 S198 S199
BS04	ADP	A	N125 P126 S179 G180 G182 K183 T184 E185 N242	N93 P94 S147 G148 G150 K151 T152 E153 N195

Gene Ontology

Molecular Function

• GO:0003774 cytoskeletal motor activity
• GO:0005524 ATP binding
• GO:0051015 actin filament binding

Cellular Component

• GO:0016459 myosin complex

External links

• PDB: RCSB:5t45, PDBe:5t45, PDBj:5t45
• PDBsum: 5t45
• PubMed: 27815532
• UniProt: P10587|MYH11_CHICK Myosin-11 (Gene Name=MYH11)