Structure of PDB 5t3q Chain A

Receptor sequence
>5t3qA (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
TVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGHFGCVYHGTLLDND
GKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEG
SPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFV
HRDLAARNCMLDEKFTVKVADLPVKWMALESLQTQKFTTKSDVWSFGVLL
WELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPK
AEMRPSFSELVSRISAIFSTFIGEHYVH
3D structure
PDB5t3q Discovery of AMG337: Using structure guided scaffold hydridization to optimize physicochemical properties and target coverage of a MET kinase inhibitor
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1204 A1206 R1208 N1209 D1222
Catalytic site (residue number reindexed from 1) D153 A155 R157 N158 D171
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 75H A I1084 V1092 A1108 F1124 M1131 L1157 Y1159 M1160 M1211 D1222 I35 V41 A57 F73 M80 L106 Y108 M109 M160 D171 BindingDB: Ki=2.7nM,IC50=2.7nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5t3q, PDBe:5t3q, PDBj:5t3q
PDBsum5t3q
PubMed
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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