Structure of PDB 5t3o Chain A

Receptor sequence
>5t3oA (length=307) Species: 274 (Thermus thermophilus) [Search protein sequence]
PLLIFSGQSNRPLAQAIAEALGLPLGKSTTLRFANDNLFVRYEESLREGD
VFIVQSFVPPVQDHLMELLMMVDAAKGASAARVTAVIPYFSYARSDKKDA
PRISITARLIADLLQTAGADRVLTMTLHSPQVHGFFKIPVDHLSAEPVIA
NYFATRVDLENAVVVAPDAGDLKRASALARRLGLPLAFIDKERVSDTEVR
VRMLVGEVEGKTALIVDDEISTAGSLVEAVEALMQAGAKEVYAAATHGVY
VGPALDRIAKSPVKEVAATDTCPPKEGPKLRTLTVAPLFAEAIWRIHRGE
SVSSLFT
3D structure
PDB5t3o Crystal structure of recombinant phosphoribosylpyrophosphate synthetase 2 from Thermus thermophilus HB27 complexed with ADP and sulfate ions.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.6.1: ribose-phosphate diphosphokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R97 S98 D102 H131 R196 R94 S95 D99 H128 R193
BS02 SO4 A S48 R50 S45 R47
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004749 ribose phosphate diphosphokinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process
GO:0006164 purine nucleotide biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0002189 ribose phosphate diphosphokinase complex
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:5t3o, PDBe:5t3o, PDBj:5t3o
PDBsum5t3o
PubMed28580926
UniProtQ5SHU3

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