Structure of PDB 5t3f Chain A

Receptor sequence

>5t3fA (length=129) Species: 9031 (Gallus gallus)

KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGS
TDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVS
DGNGMNAWVAWRNRCKGTDVQAWIRGCRL

3D structure

• PDB: 5t3f Selenourea: a convenient phasing vehicle for macromolecular X-ray crystal structures.
• Chain: A
• Resolution: 1.45 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): E35 N46 D48 S50 D52 N59
• Catalytic site (residue number reindexed from 1): E35 N46 D48 S50 D52 N59
• Enzyme Commision number: 3.2.1.17: lysozyme.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SEY	A	N59 W63	N59 W63
BS02	SEY	A	N44 N46	N44 N46
BS03	SEY	A	R68 P70	R68 P70
BS04	SEY	A	K33 W123	K33 W123
BS05	SEY	A	N65 I78 P79	N65 I78 P79
BS06	SEY	A	C76 N93 C94 K97	C76 N93 C94 K97
BS07	SEY	A	W62 W63 I98 A107	W62 W63 I98 A107
BS08	SEY	A	T43 N44 R45	T43 N44 R45
BS09	SEY	A	F34 R114 T118 W123	F34 R114 T118 W123

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0005515 protein binding
• GO:0016231 beta-N-acetylglucosaminidase activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0042802 identical protein binding

Biological Process

• GO:0016998 cell wall macromolecule catabolic process
• GO:0031640 killing of cells of another organism
• GO:0042742 defense response to bacterium
• GO:0050829 defense response to Gram-negative bacterium
• GO:0050830 defense response to Gram-positive bacterium

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum

External links

• PDB: RCSB:5t3f, PDBe:5t3f, PDBj:5t3f
• PDBsum: 5t3f
• PubMed: 27841370
• UniProt: P00698|LYSC_CHICK Lysozyme C (Gene Name=LYZ)