Structure of PDB 5t2u Chain A

Receptor sequence
>5t2uA (length=241) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
HMELEGLTALVTGGTSGIGLESARLMAAEGADVVITGRDAQRGEQAAADI
GHGARFVQADLGDLDSVADLAAQAPDVDILVNNAGIYPQASTFDQDVAGF
QQLFDTNVRGTYFLVAAAAKGMVARGHGSIVNITTLAAHKGFPGTSVYGA
TKAALESLTRTWAAEFGANGVRVNSVSPGPTRTPTTLEQLGDFIDDVAAG
LPLRRTAAPEEIAQAVLFLASPRASFVTGSTLYVDGGGYAV
3D structure
PDB5t2u Binding of NADP(+) triggers an open-to-closed transition in a mycobacterial FabG beta-ketoacyl-ACP reductase.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G16 T134 T144 Y147 K151
Catalytic site (residue number reindexed from 1) G17 T135 T145 Y148 K152
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G12 G16 R37 D38 R41 D59 L60 N82 A83 Y86 I132 T134 Y147 K151 P177 P179 T180 T182 T184 T185 G13 G17 R38 D39 R42 D60 L61 N83 A84 Y87 I133 T135 Y148 K152 P178 P180 T181 T183 T185 T186
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

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Molecular Function
External links
PDB RCSB:5t2u, PDBe:5t2u, PDBj:5t2u
PDBsum5t2u
PubMed28126742
UniProtA0R723

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