Structure of PDB 5t2s Chain A

Receptor sequence
>5t2sA (length=247) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
HMTPKELLEWQTNWKKIMKRDSRIYFDITDDVEMNTYNKSKMDKRRDLLK
RGFLTLGAQITQFFDTTVTIVITRRSVENIYLLKDTDILSRAKKNYMKVW
SYEKAARFLKNLDVDIGENIVCRVICTTGQIPIRDLSADISQVLKEKRSI
KKVWTFGRNPACDYHLGNISRLSNKHFQILLGEDGNLLLNDISTNGTWLN
GQKVEKNSNQLLSQGDEITVGVGVESDILSLVIFINDKFKQCLEQNK
3D structure
PDB5t2s AND' logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide A R273 S285 R286 L287 S288 N289 T309 N310 R158 S170 R171 L172 S173 N174 T194 N195
External links
PDB RCSB:5t2s, PDBe:5t2s, PDBj:5t2s
PDBsum5t2s
PubMed27681475
UniProtP22216|RAD53_YEAST Serine/threonine-protein kinase RAD53 (Gene Name=RAD53);
P32325|DBF4_YEAST DDK kinase regulatory subunit DBF4 (Gene Name=DBF4)

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