Structure of PDB 5t2l Chain A

Receptor sequence
>5t2lA (length=830) Species: 10090 (Mus musculus) [Search protein sequence]
VKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLG
WVEWLQYSFPLQLEPNRALLVNVKFEGSEESFTFQVSTKDMPLALMACAL
RKKATVFRQQPEEYALQVNGRHEYLYGNYPLCHFQYICSCLHSGLTPHLT
MVHSSSILAMRDEQSNLWSLEQPFSIELIEGRKVNAMKLVVQAGLFHGNE
MLCKTVSSSEVNVCSEPVWKQRLEFDISVCDLPRMARLCFALYAVVDCPI
AWANLMLFDYKDQLKTGERCLYMWPSVLLNPAGTVRGNPNTESAAALVIY
LPEVAPVYFPALEKILELGRHEEQLQLREILERELYEHEKDLVWKMRHEV
QEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFP
DCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRAL
ANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEA
LSKLKALNDFVKVSSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPS
TLLEEVCVEQCTFMDSKMKPLWIMYSSEEAGSAGNVGIIFKNGDDLRQDM
LTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQ
LNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYV
LGIGDRHSDNIMIRESGQLFHIDFGHFLGNFRVPFILTYDFVHVIQQGKT
NNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQY
LKDSLALGKTEEEALKHFRVKFNEALRESW
3D structure
PDB5t2l Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors.
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 74H A M752 W760 I777 Y813 I825 V828 N836 M900 I910 D911 M564 W572 I589 Y625 I637 V640 N648 M712 I722 D723 PDBbind-CN: -logKd/Ki=8.20,IC50=6.3nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
Biological Process
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0046854 phosphatidylinositol phosphate biosynthetic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5t2l, PDBe:5t2l, PDBj:5t2l
PDBsum5t2l
PubMed28017532
UniProtO35904|PK3CD_MOUSE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Gene Name=Pik3cd)

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