Structure of PDB 5t1a Chain A

Receptor sequence
>5t1aA (length=445) Species: 9606,10665 [Search protein sequence]
VKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAI
SDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTI
DRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDS
VYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGISRASKSRINIF
EMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNT
NGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVF
QMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFR
TGTWDAYPPPSREKKAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLS
NCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRRYLSVFF
3D structure
PDB5t1a Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.
ChainA
Resolution2.806 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E1011 D1020
Catalytic site (residue number reindexed from 1) E207 D216
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 73R A V37 G41 L45 Y49 W98 T117 Y120 C190 V289 E291 T292 M295 V1 G5 L9 Y13 W62 T81 Y84 C154 V414 E416 T417 M420
BS02 VT5 A L81 A241 V244 Y305 G309 E310 K311 F312 L45 A366 V369 Y430 G434 E435 K436 F437 PDBbind-CN: -logKd/Ki=7.89,IC50=13nM
BS03 ZN A H144 E1005 E238 H108 E201 E363
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:5t1a, PDBe:5t1a, PDBj:5t1a
PDBsum5t1a
PubMed27926736
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
P41597

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