Structure of PDB 5t0u Chain A

Receptor sequence

>5t0uA (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]

THKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCPDCDMAFVTSGELVRHRR
YKHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTY
KLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHC
DTVIARKSDLGVHLRKQHSY

3D structure

PDB

5t0u Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA.

Chain

Resolution

3.199 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	V306 T391 Y392 K395 Y407 S419 K423 S450	V14 T99 Y100 K103 Y115 S127 K131 S158
BS02	dna	A	R301 F303 H312 T315 F331 E336 R339 H340 Y343 K344 Y358 E362 K365 R368 H369 R377 R389 K393 R396 H397 K405 F416 Q418 T421 H425 K429 R448 D451	R9 F11 H20 T23 F39 E44 R47 H48 Y51 K52 Y66 E70 K73 R76 H77 R85 R97 K101 R104 H105 K113 F124 Q126 T129 H133 K137 R156 D159
BS03	ZN	A	C296 H312 H316	C4 H20 H24
BS04	ZN	A	C324 C327 H340 H345	C32 C35 H48 H53
BS05	ZN	A	C353 C356 H369 H373	C61 C64 H77 H81
BS06	ZN	A	C381 C384 H397 H401	C89 C92 H105 H109
BS07	ZN	A	C409 C412 H425 H430	C117 C120 H133 H138
BS08	ZN	A	C439 C442 H455 H460	C147 C150 H163 H168

External links

PDB	RCSB:5t0u, PDBe:5t0u, PDBj:5t0u
PDBsum	5t0u
PubMed	28529057
UniProt	P49711\|CTCF_HUMAN Transcriptional repressor CTCF (Gene Name=CTCF)

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