Structure of PDB 5t0j Chain A

Receptor sequence
>5t0jA (length=361) Species: 9606 (Homo sapiens) [Search protein sequence]
APPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFV
VDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDV
TYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGK
TLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLI
FFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATN
RPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFEL
LARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAK
FSATPRYMTYN
3D structure
PDB5t0j Structural basis for dynamic regulation of the human 26S proteasome.
ChainA
Resolution8.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A V172 D176 V177 P218 T220 G221 K222 I354 G382 V100 D104 V105 P146 T148 G149 K150 I282 G310
BS02 ATP A M332 G335 M260 G263
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
Biological Process
GO:0001649 osteoblast differentiation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0000932 P-body
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0022624 proteasome accessory complex
GO:0034774 secretory granule lumen
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5t0j, PDBe:5t0j, PDBj:5t0j
PDBsum5t0j
PubMed27791164
UniProtP35998|PRS7_HUMAN 26S proteasome regulatory subunit 7 (Gene Name=PSMC2)

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