Structure of PDB 5t04 Chain A

Receptor sequence
>5t04A (length=458) Species: 10116,10665 [Search protein sequence]
TSESDTAGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARS
TVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRD
ACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALL
AIPMLFTMGLQNRSADGTHPGGLVCTPIVDTATVKVVIQVNTFMSFLFPM
LVISILNTVIANKLTVMVNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLL
TKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAK
LKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLNNKRWDEAAVNL
AKSRWYNQTPNRAKRVITTFRTGTWDAYGSGSPGRVQALRHGVLVLRAVV
IAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALAYASSAI
NPILYNLV
3D structure
PDB5t04 Structure and dynamics of a constitutively active neurotensin receptor.
ChainA
Resolution3.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E1011 D1020
Catalytic site (residue number reindexed from 1) E228 D237
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D54 L55 H132 Y146 T226 T231 R327 F331 D336 W339 F344 Y347 D12 L13 H82 Y96 T176 T181 R413 F417 D422 W425 F430 Y433
BS02 TCE A G1113 F1114 S1136 R1137 G330 F331 S353 R354
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0004930 G protein-coupled receptor activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0016020 membrane
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5t04, PDBe:5t04, PDBj:5t04
PDBsum5t04
PubMed27924846
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
P20789|NTR1_RAT Neurotensin receptor type 1 (Gene Name=Ntsr1)

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