Structure of PDB 5t00 Chain A

Receptor sequence

>5t00A (length=143) Species: 9606 (Homo sapiens) [Search protein sequence]

SPHKCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRH
IRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQS
GTMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSY

3D structure

PDB

5t00 Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA.

Chain

Resolution

2.19 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	F351 V363 S364 Y392 Y407 S419 K423 S450	F32 V44 S45 Y73 Y88 S100 K104 S131
BS02	dna	A	F331 R339 H340 Y343 K344 Y358 E362 K365 R368 H369 S372 R377 Y386 R389 K393 R396 H397 T400 K405 F416 T417 Q418 T421 H425 K429 I446 R448 D451	F12 R20 H21 Y24 K25 Y39 E43 K46 R49 H50 S53 R58 Y67 R70 K74 R77 H78 T81 K86 F97 T98 Q99 T102 H106 K110 I127 R129 D132
BS03	ZN	A	C324 H340 H345	C5 H21 H26
BS04	ZN	A	C353 C356 H369 H373	C34 C37 H50 H54
BS05	ZN	A	C381 C384 H397 H401	C62 C65 H78 H82
BS06	ZN	A	C409 C412 H425 H430	C90 C93 H106 H111
BS07	ZN	A	C439 C442 H455 H460	C120 C123 H136 H141

External links

PDB	RCSB:5t00, PDBe:5t00, PDBj:5t00
PDBsum	5t00
PubMed	28529057
UniProt	P49711\|CTCF_HUMAN Transcriptional repressor CTCF (Gene Name=CTCF)