Structure of PDB 5syz Chain A

Receptor sequence
>5syzA (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
SIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMA
DQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGK
EGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFV
CLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQL
LLRLPEIRAISMQAEEYLYYKHLNGDVPNLLIEMLHA
3D structure
PDB5syz Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists.
ChainA
Resolution1.9261 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide A F354 R361 D372 M375 Q379 L531 E534 F55 R62 D73 M76 Q80 L230 E233
BS02 71W A M345 C346 I387 H390 M428 L517 M46 C47 I88 H91 M129 L218 BindingDB: EC50=398.11nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity

View graph for
Molecular Function
External links
PDB RCSB:5syz, PDBe:5syz, PDBj:5syz
PDBsum5syz
PubMed27694446
UniProtO00482|NR5A2_HUMAN Nuclear receptor subfamily 5 group A member 2 (Gene Name=NR5A2)

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