Structure of PDB 5syt Chain A
Receptor sequence
>5sytA (length=444) Species:
9606
(Homo sapiens) [
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LWEMPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTTHVPPELGQIM
DSETFEKSRLYQLDKSTFSFWSGLYSETEGTLILLFGGIPYLWRLSGRFC
GYAGFGPEYEITQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNQQT
LGFFMKDAIKKFVVTQCILLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSL
VLVTIYADYIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPLTKVYVVEGSK
RSSHSNKRIVLFDTLLEEYSVLNKEEIKAKVKNKKQGCKNEEVLAVLGHE
LGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRKELFAAFGFYDSQPTLI
GLLIIFQFIFSPYNEVLSFCLTVLSRRFEFQADAFAKKLGKAKDLYSALI
KLNKDNLGFPVSDWLFSMWHYSHPPLLERLQALKTMKQSGLEVL
3D structure
PDB
5syt
Human CaaX protease ZMPSTE24 expressed in yeast: Structure and inhibition by HIV protease inhibitors.
Chain
A
Resolution
2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number
3.4.24.84
: Ste24 endopeptidase.
Interaction with ligand
Site
#
Ligand
Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01
C8E
A
T345 N348 S411
T309 N312 S375
BS02
C8E
A
A135 L139 F171
A126 L130 F162
BS03
C8E
A
W28 Y31
W19 Y22
BS04
C8E
A
S27 S85 G89
S18 S76 G80
BS05
C8E
A
A135 G138 S142 Q158 F163 D166 R260
A126 G129 S133 Q149 F154 D157 R251
BS06
C8E
A
W80 L83
W71 L74
BS07
C8E
A
D73 F77 W141 Y144 K152
D64 F68 W132 Y135 K143
BS08
ZN
A
H335 H339 E415
H299 H303 E379
Gene Ontology
Molecular Function
GO:0003690
double-stranded DNA binding
GO:0004175
endopeptidase activity
GO:0004222
metalloendopeptidase activity
GO:0005515
protein binding
GO:0008233
peptidase activity
GO:0008235
metalloexopeptidase activity
GO:0008237
metallopeptidase activity
GO:0046872
metal ion binding
Biological Process
GO:0001889
liver development
GO:0001942
hair follicle development
GO:0003007
heart morphogenesis
GO:0003229
ventricular cardiac muscle tissue development
GO:0003231
cardiac ventricle development
GO:0003417
growth plate cartilage development
GO:0006281
DNA repair
GO:0006325
chromatin organization
GO:0006355
regulation of DNA-templated transcription
GO:0006508
proteolysis
GO:0006925
inflammatory cell apoptotic process
GO:0006974
DNA damage response
GO:0006997
nucleus organization
GO:0006998
nuclear envelope organization
GO:0007346
regulation of mitotic cell cycle
GO:0007628
adult walking behavior
GO:0008016
regulation of heart contraction
GO:0008340
determination of adult lifespan
GO:0008360
regulation of cell shape
GO:0008544
epidermis development
GO:0010506
regulation of autophagy
GO:0010628
positive regulation of gene expression
GO:0010629
negative regulation of gene expression
GO:0010906
regulation of glucose metabolic process
GO:0016485
protein processing
GO:0019216
regulation of lipid metabolic process
GO:0030282
bone mineralization
GO:0030327
prenylated protein catabolic process
GO:0030500
regulation of bone mineralization
GO:0032006
regulation of TOR signaling
GO:0032350
regulation of hormone metabolic process
GO:0035264
multicellular organism growth
GO:0040014
regulation of multicellular organism growth
GO:0040029
epigenetic regulation of gene expression
GO:0043007
maintenance of rDNA
GO:0043516
regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044029
positive regulation of gene expression via chromosomal CpG island demethylation
GO:0044255
cellular lipid metabolic process
GO:0048145
regulation of fibroblast proliferation
GO:0048538
thymus development
GO:0050688
regulation of defense response to virus
GO:0050905
neuromuscular process
GO:0051276
chromosome organization
GO:0051604
protein maturation
GO:0055013
cardiac muscle cell development
GO:0060307
regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060993
kidney morphogenesis
GO:0061337
cardiac conduction
GO:0061762
CAMKK-AMPK signaling cascade
GO:0070302
regulation of stress-activated protein kinase signaling cascade
GO:0071480
cellular response to gamma radiation
GO:0071586
CAAX-box protein processing
GO:0072423
response to DNA damage checkpoint signaling
GO:1903463
regulation of mitotic cell cycle DNA replication
GO:1903522
regulation of blood circulation
GO:1903799
negative regulation of miRNA processing
GO:1990036
calcium ion import into sarcoplasmic reticulum
GO:2000730
regulation of termination of RNA polymerase I transcription
GO:2000772
regulation of cellular senescence
Cellular Component
GO:0005634
nucleus
GO:0005635
nuclear envelope
GO:0005637
nuclear inner membrane
GO:0005768
endosome
GO:0005783
endoplasmic reticulum
GO:0005789
endoplasmic reticulum membrane
GO:0016020
membrane
GO:0031901
early endosome membrane
GO:0031902
late endosome membrane
GO:0032991
protein-containing complex
GO:0070062
extracellular exosome
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:5syt
,
PDBe:5syt
,
PDBj:5syt
PDBsum
5syt
PubMed
27774687
UniProt
O75844
|FACE1_HUMAN CAAX prenyl protease 1 homolog (Gene Name=ZMPSTE24)
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