Structure of PDB 5sy7 Chain A

Receptor sequence
>5sy7A (length=276) Species: 10090 (Mus musculus) [Search protein sequence]
LARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSH
MKSLPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQ
SEWFGSTLYDQVHPDDVDKLREQLSTSSRRSFICRMRCGTNGLGSVKEGE
PHFVVVHCTGYLVAIGRLQVTSSPEFISRHNIEGIFTFVDHRCVATVGYQ
PQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKTREWL
WMRTSSFTFQNPYSDEIEYIICTNTN
3D structure
PDB5sy7 NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.
ChainA
Resolution4.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R91 H94 S95 R99 R102 D127 K128 R3 H6 S7 R11 R14 D39 K40 PDBbind-CN: Kd=17.5nM
BS02 dna A H94 E98 R101 H6 E10 R13 PDBbind-CN: Kd=17.5nM
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5sy7, PDBe:5sy7, PDBj:5sy7
PDBsum5sy7
PubMed27782878
UniProtP53762|ARNT_MOUSE Aryl hydrocarbon receptor nuclear translocator (Gene Name=Arnt)

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