Structure of PDB 5sy2 Chain A

Receptor sequence
>5sy2A (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
TLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKC
SRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGG
ITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQG
VLKEDVFSFYYNRDSSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQI
QMKGVSVGTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDY
VVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDI
PPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
3D structure
PDB5sy2 Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors.
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D38 S41 N43 W45 D226 A229
Catalytic site (residue number reindexed from 1) D37 S40 N42 W44 D221 A224
Enzyme Commision number 3.4.23.15: renin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 74V A T18 Q19 Y20 V36 D38 G40 Y83 T85 F124 D226 T227 G228 A229 S230 T17 Q18 Y19 V35 D37 G39 Y82 T84 F123 D221 T222 G223 A224 S225 MOAD: ic50=11uM
PDBbind-CN: -logKd/Ki=4.96,IC50=11uM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5sy2, PDBe:5sy2, PDBj:5sy2
PDBsum5sy2
PubMed27687967
UniProtP00797|RENI_HUMAN Renin (Gene Name=REN)

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