Structure of PDB 5svk Chain A

Receptor sequence

>5svkA (length=357) Species: 9606 (Homo sapiens) [Search protein sequence]

FFTYETPKVIVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAI
ESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGF
CPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTE
VDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFH
PDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQC
IPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFD
VLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAK
KFEEVNE

3D structure

PDB

5svk X-ray structures define human P2X3 receptor gating cycle and antagonist action.

Chain

Resolution

2.773 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GLC	A	D250 K315	D244 K309
BS02	ATP	A	V274 S275 N279 R281 K299	V268 S269 N273 R275 K293	PDBbind-CN: -logKd/Ki=8.48,Kd=3.3nM BindingDB: EC50=340nM

Gene Ontology

	Molecular Function
GO:0001614	purinergic nucleotide receptor activity
GO:0004931	extracellularly ATP-gated monoatomic cation channel activity
GO:0005216	monoatomic ion channel activity
GO:0005524	ATP binding
GO:0015267	channel activity

	Biological Process
GO:0001666	response to hypoxia
GO:0006811	monoatomic ion transport
GO:0006812	monoatomic cation transport
GO:0007165	signal transduction
GO:0007268	chemical synaptic transmission
GO:0007274	neuromuscular synaptic transmission
GO:0009266	response to temperature stimulus
GO:0009408	response to heat
GO:0009409	response to cold
GO:0009612	response to mechanical stimulus
GO:0009743	response to carbohydrate
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0014832	urinary bladder smooth muscle contraction
GO:0030432	peristalsis
GO:0033198	response to ATP
GO:0034220	monoatomic ion transmembrane transport
GO:0035590	purinergic nucleotide receptor signaling pathway
GO:0048167	regulation of synaptic plasticity
GO:0048266	behavioral response to pain
GO:0050804	modulation of chemical synaptic transmission
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050909	sensory perception of taste
GO:0051649	establishment of localization in cell
GO:0060079	excitatory postsynaptic potential
GO:0070207	protein homotrimerization
GO:0070588	calcium ion transmembrane transport
GO:0071318	cellular response to ATP
GO:0098655	monoatomic cation transmembrane transport
GO:0098662	inorganic cation transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030424	axon
GO:0043005	neuron projection
GO:0043235	receptor complex
GO:0098685	Schaffer collateral - CA1 synapse
GO:0098686	hippocampal mossy fiber to CA3 synapse
GO:0098794	postsynapse

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:5svk, PDBe:5svk, PDBj:5svk
PDBsum	5svk
PubMed	27626375
UniProt	P56373\|P2RX3_HUMAN P2X purinoceptor 3 (Gene Name=P2RX3)

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