Structure of PDB 5std Chain A

Receptor sequence
>5stdA (length=164) Species: 148305 (Pyricularia grisea) [Search protein sequence]
GEITFSDYLGLMTCVYEWADSYDSKDWDRLRKVIAPTLRIDYRSFLDKLW
EAMPAEEFVGMVSSKQVLGDPTLRTQHFIGGTRWEKVSEDEVIGYHQLRV
PHQRYKDTTMKEVTMKGHAHSANLHWYKKIDGVWKFAGLKPDIRWGEFDF
DRIFEDGRETFGDK
3D structure
PDB5std High-resolution structures of scytalone dehydratase-inhibitor complexes crystallized at physiological pH.
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y30 D31 Y50 H85 H110
Catalytic site (residue number reindexed from 1) Y22 D23 Y42 H77 H102
Enzyme Commision number 4.2.1.94: scytalone dehydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E163 D164 E167 E155 D156 E159
BS02 UNN A F53 M69 V75 V108 N131 P149 I151 F158 F45 M61 V67 V100 N123 P141 I143 F150 MOAD: Ki=32pM
PDBbind-CN: -logKd/Ki=10.49,Ki=32pM
BindingDB: Ki=32nM
Gene Ontology
Molecular Function
GO:0016829 lyase activity
GO:0030411 scytalone dehydratase activity
GO:0046872 metal ion binding
Biological Process
GO:0006582 melanin metabolic process
GO:0042438 melanin biosynthetic process
Cellular Component
GO:0005575 cellular_component
GO:0005768 endosome

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Cellular Component
External links
PDB RCSB:5std, PDBe:5std, PDBj:5std
PDBsum5std
PubMed10382670
UniProtP56221|SCYD_PYRO7 Scytalone dehydratase (Gene Name=SDH1)

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