Structure of PDB 5scn Chain A

Receptor sequence
>5scnA (length=167) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
GLVPRGSHMVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVM
GRRTWDSLPAKVRPLPGRRNVVLSRQADFMASGAEVVGSLEEALTSPETW
VIGGGQVYALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGETGEW
RFSRSGLRYRLYSYHRS
3D structure
PDB5scn Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-25
ChainA
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.3: dihydrofolate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GUU A I5 W6 I20 R23 D27 F31 L50 P51 R60 I94 I13 W14 I28 R31 D35 F39 L58 P59 R68 I102
BS02 NAP A W6 A7 I14 D19 I20 G43 R44 R45 T46 L65 S66 R67 G80 I94 G96 G97 Q98 V99 W14 A15 I22 D27 I28 G51 R52 R53 T54 L73 S74 R75 G88 I102 G104 G105 Q106 V107
Gene Ontology
Molecular Function
GO:0004146 dihydrofolate reductase activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
GO:0070401 NADP+ binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0046452 dihydrofolate metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046655 folic acid metabolic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:5scn, PDBe:5scn, PDBj:5scn
PDBsum5scn
PubMed
UniProtP9WNX1|DYR_MYCTU Dihydrofolate reductase (Gene Name=folA)

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