Structure of PDB 5saw Chain A

Receptor sequence
>5sawA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
VDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVGHPLLVAV
KILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYM
ENGDLNQFLSAHQLEDPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRD
LATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECIL
MGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGR
QVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAE
3D structure
PDB5saw Crystal Structure of a DDR1 complex
ChainA
Resolution1.601 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1IM A A653 K655 E672 M676 L679 I685 T701 M704 H758 A777 D778 A49 K51 E68 M72 L75 I81 T97 M100 H148 A167 D168
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5saw, PDBe:5saw, PDBj:5saw
PDBsum5saw
PubMed
UniProtQ08345|DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 (Gene Name=DDR1)

[Back to BioLiP]