Structure of PDB 5sav Chain A

Receptor sequence
>5savA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
RVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVHPLLVAVKILRPDAT
KNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQF
LSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLA
TRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMG
KFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQV
YLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDA
3D structure
PDB5sav Crystal Structure of a DDR1 complex
ChainA
Resolution1.76 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1IJ A V624 A653 E672 M676 L679 I685 T701 M704 H758 L767 A777 D778 F779 V23 A41 E60 M64 L67 I73 T89 M92 H146 L155 A165 D166 F167
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5sav, PDBe:5sav, PDBj:5sav
PDBsum5sav
PubMed
UniProtQ08345|DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 (Gene Name=DDR1)

[Back to BioLiP]