Structure of PDB 5s9r Chain A

Receptor sequence
>5s9rA (length=126) Species: 9606 (Homo sapiens) [Search protein sequence]
GHMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAV
KLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYN
KPGDDIVLMAEALEKLFLQKINELPT
3D structure
PDB5s9r Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design.
ChainA
Resolution1.85 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YWA A W81 P82 F83 L92 L94 N140 I146 M149 W41 P42 F43 L52 L54 N100 I106 M109 BindingDB: IC50=<5nM
External links
PDB RCSB:5s9r, PDBe:5s9r, PDBj:5s9r
PDBsum5s9r
PubMed34543572
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

[Back to BioLiP]