Structure of PDB 5s7k Chain A

Receptor sequence
>5s7kA (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
RTVARDITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETEL
YNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLD
TVSCLRIVLSIASGLAHLHIEIFGGKPAIAHRDLKSKNILVKKNGQCCIA
DLGLAVMHSQRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEV
ARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSD
PTLTSLAKLMKECWYQNPSARLTALRIKKTLTKID
3D structure
PDB5s7k XChem group deposition
ChainA
Resolution1.31 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LU8 A V214 V222 A233 K235 T283 Y285 H286 G289 L343 A353 D354 V13 V21 A32 K34 T82 Y84 H85 G88 L140 A150 D151 BindingDB: IC50=29nM
BS02 LU8 A R202 V204 R206 W227 R1 V3 R5 W26 BindingDB: IC50=29nM
BS03 LU8 A W227 I266 W26 I65 BindingDB: IC50=29nM
BS04 XEJ A R247 G356 L357 R46 G153 L154
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5s7k, PDBe:5s7k, PDBj:5s7k
PDBsum5s7k
PubMed
UniProtQ04771|ACVR1_HUMAN Activin receptor type-1 (Gene Name=ACVR1)

[Back to BioLiP]