Structure of PDB 5s7i Chain A

Receptor sequence
>5s7iA (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
QRTVARDITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETE
LYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL
DTVSCLRIVLSIASGLAHLHIEIFGGKPAIAHRDLKSKNILVKKNGQCCI
ADLGLAVMHRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVA
RRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDP
TLTSLAKLMKECWYQNPSARLTALRIKKTLTKID
3D structure
PDB5s7i XChem group deposition
ChainA
Resolution1.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LU8 A V214 V222 A233 K235 T283 Y285 H286 G289 L343 A353 D354 V14 V22 A33 K35 T83 Y85 H86 G89 L141 A151 D152 BindingDB: IC50=29nM
BS02 LU8 A R202 V204 A205 R206 W227 R2 V4 A5 R6 W27 BindingDB: IC50=29nM
BS03 LU8 A W227 I266 W27 I66 BindingDB: IC50=29nM
BS04 HV2 A K216 G217 G220 V222 K16 G17 G20 V22
BS05 HV2 A T299 L300 D301 S304 T99 L100 D101 S104
BS06 HV2 A R485 L486 T487 R270 L271 T272
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5s7i, PDBe:5s7i, PDBj:5s7i
PDBsum5s7i
PubMed
UniProtQ04771|ACVR1_HUMAN Activin receptor type-1 (Gene Name=ACVR1)

[Back to BioLiP]