Structure of PDB 5rvx Chain A

Receptor sequence

>5rvxA (length=867) Species: 9606 (Homo sapiens)

DHGLARLVTVYCEHGHKAAKINPLFTGQALLENVPEIQALVQTLQGPFHT
AGLLNMGKEEASLEEVLVYLNQIYCGQISIETSQLQSQDEKDWFAKRFEE
LQKETFTTEERKHLSKLMLESQEFDHFLATKFSTVKRYGGEGAESMMGFF
HELLKMSAYSGITDVIIGMPHRGRLNLLTGLLQFPPELMFRKMRGLSEFP
ENFSATGDVLSHLTSSVDLYFGAHHPLHVTMLPNPSHLEAVNPVAVGKTR
GRQQSRQDGDYSPDNSAQPGDRVICLQVHGDASFCGQGIVPETFTLSNLP
HFRIGGSVHLIVNNQLGYTTPAERGRSSLYCSDIGKLVGCAIIHVNGDSP
EEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEPFYTNPIMYKII
RARKSIPDTYAEHLIAGGLMTQEEVSEIKSSYYAKLNDHLNNMAHYRPPA
LNLQAHWQGLAQPEAQITTWSTGVPLDLLRFVGMKSVEVPRELQMHSHLL
KTHVQSRMEKMMDGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGTFS
QRHAIVVCQETDDTYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGMSI
ESPKLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYD
GAGPDHSSCRIERFLQMCDSAEEGVDGDTVNMFVVHPTTPAQYFHLLRRQ
MVRNFRKPLIVASPKMLLRLPAAVSTLQEMAPGTTFNPVIGDSSVDPKKV
KTLVFCSGKHFYSLVKQRESLGAKKHDFAIIRVEELCPFPLDSLQQEMSK
YKHVKDHIWSQEEPQNMGPWSFVSPRFEKQLACKLRLVGRPPLPVPAVGI
GTVHLHQHEDILAKTFA

3D structure

• PDB: 5rvx PanDDA analysis group deposition
• Chain: A
• Resolution: 1.661 Å

Enzymatic activity

• Enzyme Commision number: 1.2.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	B0Y	A	E375 R378 S380 L381	E323 R326 S328 L329
BS02	TPP	A	H223 R224 S288 H289 L290 G332 D333 A334 S335 Q339 N366 L368 G369 H435	H171 R172 S236 H237 L238 G280 D281 A282 S283 Q287 N314 L316 G317 H383
BS03	MG	A	D333 N366 L368	D281 N314 L316
BS04	B0Y	A	N350 P352	N298 P300
BS05	TPP	A	Q594 L638 E640 Q664 F668	Q542 L586 E588 Q612 F616

Gene Ontology

Molecular Function

• GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity
• GO:0005515 protein binding
• GO:0016491 oxidoreductase activity
• GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
• GO:0030976 thiamine pyrophosphate binding
• GO:0160166 2-oxoadipate dehydrogenase activity

Biological Process

• GO:0002244 hematopoietic progenitor cell differentiation
• GO:0006091 generation of precursor metabolites and energy
• GO:0006096 glycolytic process

Cellular Component

• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix
• GO:0160167 oxoadipate dehydrogenase complex

External links

• PDB: RCSB:5rvx, PDBe:5rvx, PDBj:5rvx
• PDBsum: 5rvx
• UniProt: Q96HY7|DHTK1_HUMAN 2-oxoadipate dehydrogenase complex component E1 (Gene Name=DHTKD1)