Structure of PDB 5rvm Chain A

Receptor sequence
>5rvmA (length=173) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
SNAGEVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGG
GVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVG
PNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTV
RTNVYLAVFDKNLYDKLVSSFLE
3D structure
PDB5rvm Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.
ChainA
Resolution1.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HBD A V3 K31 P32 T33 K90 V6 K34 P35 T36 K93
External links
PDB RCSB:5rvm, PDBe:5rvm, PDBj:5rvm
PDBsum5rvm
PubMed33853786
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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