Structure of PDB 5r8i Chain A

Receptor sequence
>5r8iA (length=152) Species: 9606 (Homo sapiens) [Search protein sequence]
APVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGE
ESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFV
FNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQF
VS
3D structure
PDB5r8i Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes.
ChainA
Resolution1.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A7N A E25 L26 P131 E25 L26 P131
Gene Ontology
Molecular Function
GO:0005125 cytokine activity
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
Cellular Component
GO:0005615 extracellular space

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Cellular Component
External links
PDB RCSB:5r8i, PDBe:5r8i, PDBj:5r8i
PDBsum5r8i
PubMed32543856
UniProtP01584|IL1B_HUMAN Interleukin-1 beta (Gene Name=IL1B)

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