Structure of PDB 5qpp Chain A

Receptor sequence
>5qppA (length=361) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
MASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYF
RGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDI
MDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLK
DLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIY
KRIVKYKTTFYTYLLPLVMGLLVSEAAASVEMNLVERVAHLIGEYFQVQD
DVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGEK
DPAKVAVVKRLYSKANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESV
AVVWEKTHKRK
3D structure
PDB5qpp PanDDA analysis group deposition - FPPS screened against the DSI Fragment Library
ChainA
Resolution1.48 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K48 H93 D98 D102 R107 D170 K207 F246 D250 D251
Catalytic site (residue number reindexed from 1) K48 H93 D98 D102 R107 D170 K207 F246 D250 D251
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D98 D102 D98 D102
BS02 LV4 A K48 F50 Y213 F246 T357 R360 K48 F50 Y213 F246 T357 R360
BS03 LV4 A K158 F210 E236 K158 F210 E236
BS04 LV4 A D151 L155 V218 M232 E236 D151 L155 V218 M232 E236
BS05 LV4 A V252 F256 Y312 S313 Q318 F321 V252 F256 Y312 S313 Q318 F321
Gene Ontology
Molecular Function
GO:0004659 prenyltransferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
Biological Process
GO:0008299 isoprenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5qpp, PDBe:5qpp, PDBj:5qpp
PDBsum5qpp
PubMed
UniProtQ8WS26

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