Structure of PDB 5qop Chain A

Receptor sequence
>5qopA (length=149) Species: 9606 (Homo sapiens) [Search protein sequence]
GVPTYGAIILDETLENVLLVQGYLAKSGWGFPKGKVNKEEAPHDCAAREV
FEETGFDIKDYICKDDYIELRINDQLARLYIIPGIPKDTKFNPKTRREIR
NIEWFSIEKLPCHRNDMTPKSKLGLAPNKFFMAIPFIRPLRDWLSRRFG
3D structure
PDB5qop PanDDA analysis group deposition
ChainA
Resolution1.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.62: 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LDD A K121 K128 G129 K26 K33 G34
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0140933 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA

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Molecular Function
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Biological Process
External links
PDB RCSB:5qop, PDBe:5qop, PDBj:5qop
PDBsum5qop
PubMed
UniProtQ8IU60|DCP2_HUMAN m7GpppN-mRNA hydrolase (Gene Name=DCP2)

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