Structure of PDB 5qj1 Chain A

Receptor sequence
>5qj1A (length=543) [Search protein sequence]
SMSYSWTGALITPCSPEEEKLPINPLSNSSLRYHNKVYCTTSKSASQRAK
KVTFDRTQVLDAHYDSVLKDIKLAASKVSARLLTLEEACQLTPPHSARSK
YGFGAKEVRSLSGRAVNHIKSVWKDLLEDPQTPIPTTIMAKNEVFCVDGK
KPARLIVYPDLGVRVCEKMALYDITQKLPQAVMGASYGFQYSPAQRVEYL
LKAWAEKKDPMGFSYDTRCFDSTVTERDIRTEESIYQACSLPEEARTAIH
SLTERLYVGGPMFNSKGQTCGYRRCRASGVLTTSMGNTITCYVKALAACK
AAGIVAPTMLVCGDDLVVISESQGTEEDERNLRAFTEAMTRYSAPPGDPP
RPEYDLELITSCSSNVSVALGPRGRRRYYLTRDPTTPLARAAWETVRHSP
INSWLGNIIQYAPTIWVRMVLMTHFFSILMVQDTLDQNLNFEMYGSVYSV
NPLDLPAIIERLHGLDAFSMHTYSHHELTRVASALRKLGAPPLRVWKSRA
RAVRASLISRGGKAAVCGRYLFNWAVKTKLKLTPLPEARLLDL
3D structure
PDB5qj1 Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors.
ChainA
Resolution2.17 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J6J A F193 Y195 R200 L204 L314 I363 S365 C366 S368 Q414 Y415 Y448 L466 F189 Y191 R196 L200 L310 I359 S361 C362 S364 Q410 Y411 Y444 L462
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5qj1, PDBe:5qj1, PDBj:5qj1
PDBsum5qj1
PubMed30613329
UniProtQ99IB8|POLG_HCVJF Genome polyprotein

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