Structure of PDB 5qin Chain A

Receptor sequence
>5qinA (length=295) Species: 9606 (Homo sapiens) [Search protein sequence]
ELLPIELDTLVGKGRFAEVYKAKLKQFETVAVKIFPYEEYASWKTEKDIF
SDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISW
EDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCC
LCDFGLSLRLDPTLSVDDLANQVGTARYMAPEVLASAMNLENVESFKQTD
VYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVASMADNVLADAG
RPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL
3D structure
PDB5qin Discovery of 4-Azaindole Inhibitors of TGF beta RI as Immuno-oncology Agents.
ChainA
Resolution1.57 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D379 K381 N384 D397 T421
Catalytic site (residue number reindexed from 1) D135 K137 N140 D153 T175
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 J2V A V258 A275 K277 F294 L305 L323 T325 F327 H328 G331 L386 C396 D397 V19 A31 K33 F50 L61 L79 T81 F83 H84 G87 L142 C152 D153 PDBbind-CN: -logKd/Ki=10.40,IC50=0.04nM
BindingDB: IC50=40nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5qin, PDBe:5qin, PDBj:5qin
PDBsum5qin
PubMed30429955
UniProtP37173|TGFR2_HUMAN TGF-beta receptor type-2 (Gene Name=TGFBR2)

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