Structure of PDB 5qbz Chain A

Receptor sequence
>5qbzA (length=217) Species: 9606 (Homo sapiens) [Search protein sequence]
LPDSVDWREKGCVTEVKYQGSCGASWAFSAVGALEAQLKLKTGKLVSLSA
QNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQ
YDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRS
GVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMAR
NKGNHCGIASFPSYPEI
3D structure
PDB5qbz Crystal structure of human Cathepsin-S with bound ligand
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 S25 H164 N184
Catalytic site (residue number reindexed from 1) Q19 S25 H164 N184
Enzyme Commision number 3.4.22.27: cathepsin S.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B8Y A G62 K64 N67 G68 G69 F70 V162 N163 G165 F211 G62 K64 N67 G68 G69 F70 V162 N163 G165 F211 BindingDB: IC50=8000nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5qbz, PDBe:5qbz, PDBj:5qbz
PDBsum5qbz
PubMed
UniProtP25774|CATS_HUMAN Cathepsin S (Gene Name=CTSS)

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