Structure of PDB 5ph6 Chain A

Receptor sequence
>5ph6A (length=331) Species: 9606 (Homo sapiens) [Search protein sequence]
AQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKAR
ETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKY
QTPPHQNFEDLERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTI
QDLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPK
TWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKENGIP
FNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQC
SCGEARVTFSMDAFVRILQPERYDLWKRGQD
3D structure
PDB5ph6 A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
ChainA
Resolution1.742 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G174 Y181 H192 E194 H280 A292
Catalytic site (residue number reindexed from 1) G164 Y171 H182 E184 H270 A282
Enzyme Commision number 1.14.11.66: [histone H3]-trimethyl-L-lysine(9) demethylase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 ZN A C238 H244 C310 C312 C228 H234 C300 C302
BS02 ISN A Q309 C310 S311 L335 W336 G339 Q299 C300 S301 L325 W326 G329
BS03 ISN A C168 I301 K305 C158 I291 K295
External links
PDB RCSB:5ph6, PDBe:5ph6, PDBj:5ph6
PDBsum5ph6
PubMed28436492
UniProtQ6B0I6|KDM4D_HUMAN Lysine-specific demethylase 4D (Gene Name=KDM4D)

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