Structure of PDB 5p9n Chain A

Receptor sequence

>5p9nA (length=213) Species: 10116 (Rattus norvegicus) [Search protein sequence]

DTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDA
VIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEINPDCAAITQQM
LNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTL
LLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMK
VVDGLEKAIYQGP

3D structure

PDB

5p9n Crystal Structure of a COMT complex

Chain

Resolution

1.17 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D141 K144 D169 N170 E199
Catalytic site (residue number reindexed from 1)	D139 K142 D167 N168 E197
Enzyme Commision number	2.1.1.6: catechol O-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MG	A	D141 D169 N170	D139 D167 N168
BS02	7JE	A	W38 M40 G66 E90 I91 S119 D141 H142 W143 K144 N170 P174 E199	W36 M38 G64 E88 I89 S117 D139 H140 W141 K142 N168 P172 E197
BS03	8JE	A	W38 M40 E90 I91 S119 D141 H142 W143 K144 N170 P174 E199	W36 M38 E88 I89 S117 D139 H140 W141 K142 N168 P172 E197

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0008171	O-methyltransferase activity
GO:0016206	catechol O-methyltransferase activity

	Biological Process
GO:0006584	catecholamine metabolic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:5p9n, PDBe:5p9n, PDBj:5p9n
PDBsum	5p9n
PubMed
UniProt	P22734\|COMT_RAT Catechol O-methyltransferase (Gene Name=Comt)

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