Structure of PDB 5oy3 Chain A

Receptor sequence

>5oy3A (length=450) Species: 9606 (Homo sapiens) [Search protein sequence]

ESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCT
DPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDEN
WDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESHIIKFGTNIDLSDAK
RWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSRTP
GHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWW
PILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPL
TAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKF
CLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFV
TSEGSRNTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTLAPA

3D structure

PDB

5oy3 Structural Basis of Histone Demethylase KDM6B Histone 3 Lysine 27 Specificity.

Chain

Resolution

2.136 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	E1244 R1246 S1270 S1271 R1272 N1331 D1333 L1371 G1372 Q1377 G1435 N1484 Q1564 V1567 Y1573 D1579 T1597 Y1598	E88 R90 S114 S115 R116 N143 D145 L183 G184 Q189 G247 N296 Q376 V379 Y385 D391 T408 Y409
BS02	FE	A	H1390 E1392 H1470	H202 E204 H282
BS03	ZN	A	C1575 C1578 C1602 C1605	C387 C390 C413 C416
BS04	AKG	A	K1381 T1387 H1390 S1398 N1400 H1470	K193 T199 H202 S210 N212 H282

External links

PDB	RCSB:5oy3, PDBe:5oy3, PDBj:5oy3
PDBsum	5oy3
PubMed	29220567
UniProt	O15054\|KDM6B_HUMAN Lysine-specific demethylase 6B (Gene Name=KDM6B)

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