Structure of PDB 5owt Chain A

Receptor sequence
>5owtA (length=203) Species: 9606 (Homo sapiens) [Search protein sequence]
GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVC
NKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYI
GGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRV
TLGKSFLQFSAPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIM
RPE
3D structure
PDB5owt 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F37 A H1031 G1032 P1034 F1035 H1048 A1049 Y1050 Y1060 S1068 Y1071 H80 G81 P83 F84 H97 A98 Y99 Y109 S117 Y120 PDBbind-CN: -logKd/Ki=8.17,IC50=6.7nM
BS02 ZN A C1081 H1084 C1089 C1092 C130 H133 C138 C141
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5owt, PDBe:5owt, PDBj:5owt
PDBsum5owt
PubMed29374194
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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