Structure of PDB 5ovr Chain A

Receptor sequence
>5ovrA (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
NLYFQSMSRVLQAEELHEKALDPFLLQAEFFEIPMNFVDPKEYDIPGLVR
KNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGGEEKVYIATQG
PIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYDGVEI
TVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHL
VREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDI
LKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQLSH
3D structure
PDB5ovr X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.
ChainA
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D437 C472 R478 T479 Q516
Catalytic site (residue number reindexed from 1) D187 C222 R228 T229 Q266
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AXK A N376 E378 E379 S434 W435 P436 D437 K439 R443 R478 Q520 N126 E128 E129 S184 W185 P186 D187 K189 R193 R228 Q270 MOAD: Kd=27.2uM
PDBbind-CN: -logKd/Ki=4.57,Kd=27.2uM
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5ovr, PDBe:5ovr, PDBj:5ovr
PDBsum5ovr
PubMed29116812
UniProtP54829|PTN5_HUMAN Tyrosine-protein phosphatase non-receptor type 5 (Gene Name=PTPN5)

[Back to BioLiP]