Structure of PDB 5ovi Chain A

Receptor sequence
>5oviA (length=466) Species: 9606 (Homo sapiens) [Search protein sequence]
QMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERLTYHMYADP
NFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLS
AELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTV
RGKAMKKWVESITKIIQRKKIARDTFQSSPPTVEWHISRPGHIETFDLLT
LHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHT
TNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAM
NSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVP
FFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQP
YCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFP
KKYSYPLKSPGVRPSN
3D structure
PDB5ovi Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AXH A N879 V883 Y884 D887 F890 L901 E902 H905 N301 V305 Y306 D309 F312 L323 E324 H327 MOAD: ic50=21nM
PDBbind-CN: -logKd/Ki=7.68,IC50=21nM
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase-mediated signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:5ovi, PDBe:5ovi, PDBj:5ovi
PDBsum5ovi
PubMed30683722
UniProtQ07889|SOS1_HUMAN Son of sevenless homolog 1 (Gene Name=SOS1)

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