Structure of PDB 5ovh Chain A

Receptor sequence
>5ovhA (length=455) Species: 9606 (Homo sapiens) [Search protein sequence]
GAMAEEQMRLPSADVYRFAEPDSEENIIFEAGIPIIKAGTVIKLIERLTY
HMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEAELKRFRKEYIQP
VQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESIT
KIIQRKKIARDITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTL
LESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV
ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTF
EQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKT
EEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRF
FENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGV
RPSNP
3D structure
PDB5ovh Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
ChainA
Resolution2.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AWW A M878 N879 V883 Y884 F890 E902 H905 M288 N289 V293 Y294 F300 E312 H315 MOAD: ic50=280nM
PDBbind-CN: -logKd/Ki=6.55,IC50=280nM
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase-mediated signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5ovh, PDBe:5ovh, PDBj:5ovh
PDBsum5ovh
PubMed30683722
UniProtQ07889|SOS1_HUMAN Son of sevenless homolog 1 (Gene Name=SOS1)

[Back to BioLiP]