Structure of PDB 5ovf Chain A

Receptor sequence
>5ovfA (length=472) Species: 9606 (Homo sapiens) [Search protein sequence]
GAMAEEQMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIERLTY
HMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIEN
GDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRME
EFIGTVRGKAMKKWVESITKIIQRKKIARDFQSSPPTVEWHISRPGHIET
FDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLK
MIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLE
VVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSIN
PPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQ
YQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKP
LPRFPKKYSYPLKSPGVRPSNP
3D structure
PDB5ovf Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
ChainA
Resolution2.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AWT A M878 N879 Y884 F890 K898 E902 H905 M305 N306 Y311 F317 K325 E329 H332 MOAD: ic50=140nM
PDBbind-CN: -logKd/Ki=6.85,IC50=140nM
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase-mediated signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:5ovf, PDBe:5ovf, PDBj:5ovf
PDBsum5ovf
PubMed30683722
UniProtQ07889|SOS1_HUMAN Son of sevenless homolog 1 (Gene Name=SOS1)

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