Structure of PDB 5ov8 Chain A

Receptor sequence
>5ov8A (length=111) Species: 9606 (Homo sapiens) [Search protein sequence]
QLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDFFTM
KQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGAV
LRQARRQAEKM
3D structure
PDB5ov8 Structure-based discovery of selective BRPF1 bromodomain inhibitors.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AXN A I652 F653 V657 P658 E661 Y707 N708 F714 I24 F25 V29 P30 E33 Y79 N80 F86 MOAD: Kd=18uM
PDBbind-CN: -logKd/Ki=4.74,Kd=18uM
BindingDB: Kd=18000nM,IC50=11000nM
External links
PDB RCSB:5ov8, PDBe:5ov8, PDBj:5ov8
PDBsum5ov8
PubMed29902720
UniProtP55201|BRPF1_HUMAN Peregrin (Gene Name=BRPF1)

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