Structure of PDB 5osy Chain A

Receptor sequence
>5osyA (length=300) Species: 9606 (Homo sapiens) [Search protein sequence]
SAPVRLPFSGFRLQKVLRESARDKIIFLHGKVNEASGDGDGEDAVVILEK
TPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPAT
EKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEA
DRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPE
HLPLLRNILHQGQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFE
APGSGVERAHLLAEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQ
3D structure
PDB5osy 5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes.
ChainA
Resolution2.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.59: 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AJQ A R54 D59 I61 E85 K142 Y143 W175 E185 D205 L206 K207 Y217 H268 S272 Y273 P288 R294 R18 D23 I25 E49 K106 Y107 W139 E149 D169 L170 K171 Y181 H232 S236 Y237 P252 R258 MOAD: ic50=0.0447uM
PDBbind-CN: -logKd/Ki=7.37,IC50=0.0430uM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
Biological Process
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA

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Molecular Function
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Biological Process
External links
PDB RCSB:5osy, PDBe:5osy, PDBj:5osy
PDBsum5osy
PubMed29676910
UniProtQ96C86|DCPS_HUMAN m7GpppX diphosphatase (Gene Name=DCPS)

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