Structure of PDB 5osw Chain A

Receptor sequence

>5oswA (length=583) Species: 9925 (Capra hircus)

DTHKSEIAHRFNDLGEENFQGLVLIAFSQYLQQCPFDEHVKLVKELTEFA
KTCVADESHAGCDKSLHTLFGDELCKVATLRETYGDMADCCEKQEPERNE
CFLKHKDDSPDLPKLKPEPDTLCAEFKADEKKFWGKYLYEVARRHPYFYA
PELLYYANKYNGVFQECCQAEDKGACLLPKIETMREKVLASSARQRLRCA
SIQKFGERALKAWSVARLSQKFPKADFTDVTKIVTDLTKVHKECCHGDLL
ECADDRADLAKYICDHQDTLSSKLKECCDKPVLEKSHCIAEIDKDAVPEN
LPPLTADFAEDKEVCKNYQEAKDVFLGSFLYEYSRRHPEYAVSVLLRLAK
EYEATLEDCCAKEDPHACYATVFDKLKHLVDEPQNLIKKNCELFEKHGEY
GFQNALIVRYTRKAPQVSTPTLVEISRSLGKVGTKCCAKPESERMPCTED
YLSLILNRLCVLHEKTPVSEKVTKCCTESLVNRRPCFSDLTLDETYVPKP
FDGESFTFHADICTLPDTEKQIKKQTALVELLKHKPKATDEQLKTVMENF
VAFVDKCCAADDKEGCFLLEGPKLVASTQAALA

3D structure

• PDB: 5osw Crystal structures of serum albumins from domesticated ruminants and their complexes with 3,5-diiodosalicylic acid.
• Chain: A
• Resolution: 1.78 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	DIU	A	Y149 R217 L218 K221 L237 R256 L259 A260 A290	Y149 R217 L218 K221 L237 R256 L259 A260 A290
BS02	DIU	A	L197 R198 S201 W213 D450 L454	L197 R198 S201 W213 D450 L454
BS03	DIU	A	L386 I387 N390 R409 E449 L452 R484 S488	L386 I387 N390 R409 E449 L452 R484 S488
BS04	DIU	A	Y137 Y160 M184	Y137 Y160 M184
BS05	DIU	A	H397 G401 N404 A405 L528 D540	H397 G401 N404 A405 L528 D540
BS06	DIU	A	F36 V40 K132	F36 V40 K132
BS07	JEF	A	A209 W213 L346 L480 V481	A209 W213 L346 L480 V481

Gene Ontology

Molecular Function

• GO:0008289 lipid binding
• GO:0046872 metal ion binding

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0072562 blood microparticle

External links

• PDB: RCSB:5osw, PDBe:5osw, PDBj:5osw
• PDBsum: 5osw
• PubMed: 29095162
• UniProt: B3VHM9